Association of MTHFR 677C>T genetic polymorphism with hyperhomocysteinemia in type 2 diabetes patients

To explore the association of serum hyperhomocysteinaemia with 677C>T polymorphism in MTHFR gene among metformin-treated patients with type 2 diabetes. Serum-homocysteine levels of 227 diabetic subjects were measured before and after the metformin administration were analyzed statistically with respect to their genotype data for MTHFR 677C>T polymorphism. CC was the most prevalent genotype at MTHFR 677C>T in our sample and associated with the lowest homocysteine level. The patients with TT genotype had significantly elevated homocysteine compared with CC following metformin use (ORBaseline = 3.434 and 95% CI:0.622–4.127 vs. OREndpoint = 4.466 95% CI:3.124–5.53). A distinct statistical association between hyperhomocysteinaemia and the carriage of MTHFR 677C>T polymorphism was established among Indian diabetic patients who were treated with metformin. Our study underscores the importance of phamacogenetic analysis in diabetes-related therapeutics. Subjects: Endocrinology; Genetics; Statistics for the Biological Sciences